CD11c Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8 T Cells
نویسندگان
چکیده
The peripheral lymphocyte pool size is governed by homeostatic mechanisms. Thus, grafted T cells expand and replenish T cell compartments in lymphopenic hosts. Lymphopenia-driven proliferation of naive CD8 T cells depends on self-peptide/MHC class I complexes and the cytokine IL-7. Lymphopenia-driven proliferation and maintenance of memory CD8 T cells are MHC independent, but are believed to require IL-7 and contact with a bone marrow-derived cell that presents the cytokine IL-15 by virtue of its high affinity receptor (IL-15R ). In this study we show that optimal spontaneous proliferation of grafted naive and memory CD8 T cells in mice rendered lymphopenic through gene ablation or irradiation requires the presence of CD11c dendritic cells. Our results suggest a dual role of CD11c dendritic cells as unique APC and cytokine-presenting cells. The Journal of Immunology, 2005, 175: 6428–6435.
منابع مشابه
CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells.
The peripheral lymphocyte pool size is governed by homeostatic mechanisms. Thus, grafted T cells expand and replenish T cell compartments in lymphopenic hosts. Lymphopenia-driven proliferation of naive CD8+ T cells depends on self-peptide/MHC class I complexes and the cytokine IL-7. Lymphopenia-driven proliferation and maintenance of memory CD8+ T cells are MHC independent, but are believed to ...
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